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In a very recent review, we reported the identification and the characterization of a whole new atypical opioid receptor with unique unfavorable regulatory Attributes toward opioid peptides.1 Our results confirmed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is additionally a broad-spect